Peter Zhang

Headshot of Peter Zhang
“We should publish great science, but more importantly, we must translate it into therapeutics to benefit patients — after all, at the end of the day, we are all patients.” — Atul Butte

Hi! Thanks for taking the time to learn a little more about me. I hope this page gives you a sense of what motivates me as a scientist, the work I've done, and where I hope to go next.

I am currently a Research Fellow at The Rockefeller University in the Laboratory of RNA Structural Biology and Biophysics. Here, I am developing cryo-EM image-processing and computational methods to move beyond describing biomolecules as single static structures and toward resolving the distributions of conformational states that make up RNA structural ensembles.

At the same time, I am completing my Ph.D., where I develop and apply coarse-grained molecular dynamics simulations to understand RNA biophysics, including single-stranded RNA and its phase-separation behavior, as well as poly(ADP-ribose).

My long-term goal is to develop therapies that improve patients' outcomes and quality of life, a motivation shaped in part by seeing diseases such as cancer affect people close to me. In the near term, I hope to work at the intersection of cryo-EM, molecular modeling, and machine learning. I am particularly interested in using molecular dynamics simulations and computational inference to characterize heterogeneous structural ensembles – thinking beyond a single static structure.

Ultimately, I want to understand how these dynamic molecular machines function in our bodies, and how we can leverage that knowledge to design better therapeutics.

If you are looking for a scientist with expertise in computational molecular modeling and cryo-EM, I would love to connect and see how I might contribute. I am always excited to learn, collaborate across disciplines, and help tackle challenging problems at the interface of computation, structural biology, and drug discovery.

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